Article

Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells

2022-02-17

Abstract excerpt

Induced pluripotent stem cells (iPSCs) can in principle differentiate into any cell of the body, and have revolutionized biomedical research and regenerative medicine. Unlike their human counterparts, mouse iPSCs (miPSCs) are reported to silence transposable elements (TEs) and prevent TE-mediated mutagenesis. Here we applied short-read or Oxford Nanopore Technologies (ONT) long-read genome sequencing to 38 bulk mi...

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Literature Corpus work: d0eef976-4c8e-5163-b22e-f7018e4cd427
DOI: 10.1101/2022.02.16.480772

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