Article

Mutational and functional heterogeneity of homology-directed repair deficiency and clinical implications

2026-05-29

Abstract excerpt

<h4>SUMMARY</h4> Homology-directed repair deficiency (HRd) encompasses mutations in multiple genes yet is treated clinically as a single entity. Here, through parallel analyses of isogenic knockouts of multiple HR pathway genes, integrating multi-omic analyses with genome-wide CRISPR-Cas9-dependency and resistance screens, we show that HRd is not a single entity but exists along a molecular and functional continu...

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Literature Corpus work: 802cec7d-599d-5ebb-ba3a-c033d00fdc30
DOI: 10.64898/2026.05.27.725139

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