Article
Expanded roles of the Fanconi anemia pathway in preserving genomic stability.
Genes & development - 15 Aug 2010
Kee Younghoon, D'Andrea Alan D
Abstract excerpt
Studying rare human genetic diseases often leads to a better understanding of normal cellular functions. Fanconi anemia (FA), for example, has elucidated a novel DNA repair mechanism required for maintaining genomic stability and preventing cancer. The FA pathway, an essential tumor-suppressive pathway, is required for protecting the human genome from a specific type of DNA damage; namely, DNA interstrand...
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