Article

CRISPR-Cas9 genome editing in human cells works via the Fanconi Anemia pathway

2017-05-09

Abstract excerpt

CRISPR-Cas9 genome editing creates targeted double strand breaks (DSBs) in eukaryotic cells that are processed by cellular DNA repair pathways. Co-administration of single stranded oligonucleotide donor DNA (ssODN) during editing can result in high-efficiency (>20%) incorporation of ssODN sequences into the break site. This process is commonly referred to as homology directed repair (HDR) and here referred to as s...

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Literature Corpus work: d00ede8c-e253-5f15-afa3-4e9a84f92e7d
DOI: 10.1101/136028

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