Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway.

Nature genetics - 1 Aug 2018

Richardson Chris D, Kazane Katelynn R, Feng Sharon J, Zelin Elena, Bray Nicholas L, Schäfer Axel J, Floor Stephen N, Corn Jacob E

Abstract excerpt

CRISPR-Cas genome editing creates targeted DNA double-strand breaks (DSBs) that are processed by cellular repair pathways, including the incorporation of exogenous DNA via single-strand template repair (SSTR). To determine the genetic basis of SSTR in human cells, we developed a coupled inhibition-cutting system capable of interrogating multiple editing outcomes in the context of thousands of individual gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clustered Regularly Interspaced Short Palindromic Repeats
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA End-Joining Repair

Share to Fanconi Anemia

Share to HCT116 Cells

Share to Jurkat Cells

Share to K562 Cells

Share to MCF-7 Cells

Source

Identifiers

PMID: 30054595
DOI: 10.1038/s41588-018-0174-0

Genes

FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway.PMID 30054595Read ↗

CRISPR-Cas9 genome editing in human cells works via the Fanconi Anemia pathwaySemantic proximity Read ↗

Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair.Semantic proximity Read ↗

Adenine base editing efficiently restores the function of Fanconi anemia hematopoietic stem and progenitor cellsSemantic proximity Read ↗

Adenine base editing is an efficient approach to restore function in FA patient cells without double-stranded DNA breaksSemantic proximity Read ↗

A novel Cas9 fusion protein promotes targeted genome editing with reduced mutational burden in primary human cellsSemantic proximity Read ↗

A comprehensive genetic catalog of human double-strand break repairSemantic proximity Read ↗

The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA.Semantic proximity Read ↗

DNA repair: exploiting the Fanconi anemia pathway as a potential therapeutic target.Semantic proximity Read ↗

Comprehensive review on Fanconi anemia: insights into DNA interstrand cross-links, repair pathways, and associated tumorsSemantic proximity Read ↗

Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer TherapySemantic proximity Read ↗

CCAR1 promotes DNA repair via an unanticipated role in alternative splicingSemantic proximity Read ↗

Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screensSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.