Article

Predicting the Three-dimensional Structure of the c- <i>KIT</i> Oncogene Promoter and the Dynamics of Strongly Coupled Guanine-Quadruplexes

2023-02-23

Abstract excerpt

<h4>ABSTRACT</h4> Guanine-quadruplexes (G4s) are non-canonical DNA structures that play important protective and regulatory roles within cells, influencing, for instance, gene expression. Although the secondary structure of many human G4s is well characterized, in several gene-promoter regions multiple G4s are located in close proximity and may form three-dimensional structures which could ultimately influence th...

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Literature Corpus work: 49979d8b-d229-59ec-88d4-c640c27a0bcc
DOI: 10.1101/2023.02.23.529733

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