Article

G-Quadruplex-Protein Interactome at Human Gene Promoters

2025-01-02

Abstract excerpt

DNA-protein interactions at gene promoters play a critical role in gene expression. The promoters of human cells are highly enriched in guanine-rich sequences, which can form four-stranded G-quadruplex (G4) structures. G4s are emerging as a distinct class of structure-based regulatory elements in gene regulation, and their interaction with proteins is essential for the role G4s play. Currently, our understanding o...

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Literature Corpus work: 0b16c39f-4fbe-5985-a2e8-915719327224
DOI: 10.1101/2025.01.01.630896

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