Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of single and double mutations on the MYC promoter G-quadruplex using a custom G4 DNA microarray: conformational landscape and nearby guanine compensation.

Nucleic acids research - 3 Jul 2026

Dickerhoff Jonathan, Tillo Desiree, Jang Jinho, Yang Danzhou, Vinson Charles

Abstract excerpt

Parallel DNA G-quadruplexes (G4) are key regulators of oncogene transcription. The MYC promoter G-quadruplex (MycG4) is a prototype parallel G4 and promising anticancer drug target. However, effects of DNA damage or mutations on their conformational landscape remain elusive. Systematic analysis of mutational effects is challenging because permutating G4-forming sequences creates a vast sequence space inaccessible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to G-Quadruplexes
Share to MYC gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine

Share to Mutation

Share to Oligonucleotide Array Sequence Analysis

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins c-myc

Source

Open in PubMed Open full text

Identifiers

PMID: 42454373
DOI: 10.1093/nar/gkag688
PMCID: PMC13369326

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of single and double mutations on the MYC promoter G-quadruplex using a custom G4 DNA microarray: conformational landscape and nearby guanine compensation.PMID 42454373Read ↗

Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes.Semantic proximity Read ↗

Stability and kinetics of c-MYC promoter G-quadruplexes studied by single-molecule manipulation.Semantic proximity Read ↗

G-quadruplexes in cancer-related gene promoters: from identification to therapeutic targetingSemantic proximity Read ↗

Mutational landscape of the G-quadruplex DNA in cMyc proto-oncogene promoter: Insights into the structural polymorphism and transcriptional regulation.Semantic proximity Read ↗

G4All: a database of experimentally confirmed G-quadruplex-forming sequencesSemantic proximity Read ↗

Epigenetic mutations: Effects on the stability of G-quadruplex structures in the c-KIT promoter.Semantic proximity Read ↗

Detect Genomic G-Quadruplexes in Living Animal Cells with a Tiny Artificial Protein ProbeSemantic proximity Read ↗

G4Killer web application: a tool to design G-quadruplex mutations.Semantic proximity Read ↗

Predicting the Three-dimensional Structure of the c- <i>KIT</i> Oncogene Promoter and the Dynamics of Strongly Coupled Guanine-QuadruplexesSemantic proximity Read ↗

Guide for phenotype-specific profiling of DNA G-quadruplex-regulated genes.Semantic proximity Read ↗

Alternative DNA structure formation in the mutagenic human c-MYC promoter.Semantic proximity Read ↗

G-Quadruplex Structures Are Key Modulators of Somatic Structural Variants in CancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.