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Article

Stability and kinetics of c-MYC promoter G-quadruplexes studied by single-molecule manipulation.

Journal of the American Chemical Society - 25 Feb 2015

You Huijuan, Wu Jingyuan, Shao Fangwei, Yan Jie

Abstract excerpt

A DNA G-quadruplex (G4) formed at the oncogene c-MYC promoter region functions as a gene silencer. Due to its high stability at physiological K(+) concentrations, its thermodynamics and kinetic properties have not been characterized in physiological solution conditions. In this work, we investigated the unfolding and folding transitions of single c-MYC G4 and several of its truncated or point mutants at 100 mM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25654467
DOI: 10.1021/ja511680u

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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