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Article

Epigenetic mutations: Effects on the stability of G-quadruplex structures in the c-KIT promoter.

International journal of biological macromolecules - 1 Jun 2026

Passarelli Assunta, Alister Diana, Di Porzio Anna, Amato Jussara, Rosu Frédéric, Gabelica Valérie, D'Aria Federica, Giancola Concetta

Abstract excerpt

G-quadruplexes (G4s) are non-canonical DNA structures that form in guanine-rich genomic regions and play key roles in the regulation of gene expression. These structures are frequently located within promoter regions and often overlap CpG islands, making them particularly sensitive to epigenetic modifications that can influence their stability and biological function. The promoter of the oncogene c-KIT contains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42214525
DOI: 10.1016/j.ijbiomac.2026.152767

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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