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Article

Mutational landscape of the G-quadruplex DNA in cMyc proto-oncogene promoter: Insights into the structural polymorphism and transcriptional regulation.

The Journal of biological chemistry - 1 Dec 2025

Su Ai-Min, Chen Qiu-Ying, Yu Xue-Yang, Lu Wen-Jing, Wang Dong, Hou Xi-Miao

Abstract excerpt

Noncanonical four-stranded DNA structures known as G-quadruplexes (G4s) play crucial roles in gene regulation and have recently been identified as hotspots for single-nucleotide variations (SNVs). In the cMyc proto-oncogene promoter, the Pu27 G4 element serves as a key transcriptional switch, yet its susceptibility to SNVs and the resulting molecular consequences remain unclear. Here, we systematically analyze...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

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Share to Proto-Oncogene Proteins c-myc

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Identifiers

PMID: 41197735
DOI: 10.1016/j.jbc.2025.110897
PMCID: PMC12704285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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