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Article

An improved model for the hTERT promoter quadruplex.

PloS one - 1 Jan 2014

Chaires Jonathan B, Trent John O, Gray Robert D, Dean William L, Buscaglia Robert, Thomas Shelia D, Miller Donald M

Abstract excerpt

Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene expression remains unexplained. We report biophysical computational studies that show that the hTERT promoter sequence forms a novel G-quadruplex structure consisting of three contiguous, stacked parallel quadruplexes. The reported hTERT mutations map to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25526084
DOI: 10.1371/journal.pone.0115580
PMCID: PMC4272262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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