Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.

Journal of the American Chemical Society - 23 Sept 2009

Hsu Shang-Te Danny, Varnai Peter, Bugaut Anthony, Reszka Anthony P, Neidle Stephen, Balasubramanian Shankar

Abstract excerpt

Guanine-rich DNA sequences with the ability to form quadruplex structures are enriched in the promoter regions of protein-coding genes, particularly those of proto-oncogenes. G-quadruplexes are structurally polymorphic and their folding topologies can depend on the sample conditions. We report here on a structural study using solution state NMR spectroscopy of a second G-quadruplex-forming motif (c-kit2) that has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deuterium Exchange Measurement
Share to G-Quadruplexes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GC Rich Sequence

Share to Hydrogen Bonding

Share to Magnetic Resonance Spectroscopy

Share to Models, Molecular

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins c-kit

Source

Open in PubMed Open full text

Identifiers

PMID: 19705869
DOI: 10.1021/ja904007p
PMCID: PMC3055164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.PMID 19705869Read ↗

A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit OncogeneSemantic proximity Read ↗

Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence.Semantic proximity Read ↗

Predicting the Three-dimensional Structure of the c- <i>KIT</i> Oncogene Promoter and the Dynamics of Strongly Coupled Guanine-QuadruplexesSemantic proximity Read ↗

Epigenetic mutations: Effects on the stability of G-quadruplex structures in the c-KIT promoter.Semantic proximity Read ↗

NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region.Semantic proximity Read ↗

Stability and kinetics of c-MYC promoter G-quadruplexes studied by single-molecule manipulation.Semantic proximity Read ↗

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexesSemantic proximity Read ↗

NMR Screen Reveals the Diverse Structural Landscape of a G-Quadruplex Library.Semantic proximity Read ↗

Duplex stem-loop-containing quadruplex motifs in the human genome: a combined genomic and structural study.Semantic proximity Read ↗

Effects of single and double mutations on the MYC promoter G-quadruplex using a custom G4 DNA microarray: conformational landscape and nearby guanine compensation.Semantic proximity Read ↗

Diffusion-ordered nuclear magnetic resonance spectroscopy for analysis of DNA secondary structural elements.Semantic proximity Read ↗

c-MYC promoter G-quadruplex formed at the 5'-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.