Alternative DNA structure formation in the mutagenic human c-MYC promoter.

doi:10.1093/nar/gkx100

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Alternative DNA structure formation in the mutagenic human c-MYC promoter.

Nucleic acids research - 5 May 2017

Del Mundo Imee Marie A, Zewail-Foote Maha, Kerwin Sean M, Vasquez Karen M

Abstract excerpt

Mutation 'hotspot' regions in the genome are susceptible to genetic instability, implicating them in diseases. These hotspots are not random and often co-localize with DNA sequences potentially capable of adopting alternative DNA structures (non-B DNA, e.g. H-DNA and G4-DNA), which have been identified as endogenous sources of genomic instability. There are regions that contain overlapping sequences that may form...

Topics

Chromosome Breakage
DNA
DNA Replication
G-Quadruplexes
Genomic Instability
Humans
Mutagens
Mutation
Nucleic Acid Conformation
Oligonucleotides
Promoter Regions, Genetic
Proto-Oncogene Proteins c-myc
Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 28334873
DOI: 10.1093/nar/gkx100
PMCID: PMC5416782

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics