The carboxy-terminus, a key regulator of protein function

Abstract excerpt

All proteins end with a carboxyl terminus that has unique biophysical properties and is often disordered. Although there are examples of important C-termini functions, a more global role for the C-terminus is not yet established. In this review, we summarize research on C-termini, a unique region in proteins that cells exploit. Alternative splicing and proteolysis increase the diversity of proteins and peptides...

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• Cellular transport and secretion
• Peptidase Inhibition and Analysis
• Ubiquitin and proteasome pathways