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Article

Structural insights into the regulation of human serine palmitoyltransferase complexes.

Nature structural & molecular biology - 1 Mar 2021

Wang Yingdi, Niu Yiming, Zhang Zhe, Gable Kenneth, Gupta Sita D, Somashekarappa Niranjanakumari, Han Gongshe, Zhao Hongtu, Myasnikov Alexander G, Kalathur Ravi C, Dunn Teresa M, Lee Chia-Hsueh

Abstract excerpt

Sphingolipids are essential lipids in eukaryotic membranes. In humans, the first and rate-limiting step of sphingolipid synthesis is catalyzed by the serine palmitoyltransferase holocomplex, which consists of catalytic components (SPTLC1 and SPTLC2) and regulatory components (ssSPTa and ORMDL3). However, the assembly, substrate processing and regulation of the complex are unclear. Here, we present 8 cryo-electron...

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PMID: 33558761
DOI: 10.1038/s41594-020-00551-9
PMCID: PMC9812531

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