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Article

Spc2 modulates substrate- and cleavage site-selection in the yeast signal peptidase complex.

The Journal of cell biology - 2 Dec 2024

Chung Yeonji, Yim Chewon, Pereira Gilberto P, Son Sungjoon, Kjølbye Lisbeth R, Mazurkiewicz Lauren E, Weeks Amy M, Förster Friedrich, von Heijne Gunnar, Souza Paulo C T, Kim Hyun

Abstract excerpt

Secretory proteins are critically dependent on the correct processing of their signal sequence by the signal peptidase complex (SPC). This step, which is essential for the proper folding and localization of proteins in eukaryotic cells, is still not fully understood. In eukaryotes, the SPC comprises four evolutionarily conserved membrane subunits (Spc1-3 and Sec11). Here, we investigated the role of Spc2,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39565596
DOI: 10.1083/jcb.202211035
PMCID: PMC11579918

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