Article
Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences.
Structure (London, England : 1993) - 3 Jul 2001
Taylor A B, Smith B S, Kitada S, Kojima K, Miyaura H, Otwinowski Z, Ito A, Deisenhofer J
Abstract excerpt
BACKGROUND: Mitochondrial processing peptidase (MPP) is a metalloendopeptidase that cleaves the N-terminal signal sequences of nuclear-encoded proteins targeted for transport from the cytosol to the mitochondria. Mitochondrial signal sequences vary in length and sequence, but each is cleaved at a single specific site by MPP. The cleavage sites typically contain an arginine at position -2 (in the N-terminal...
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