Article

EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism

2025-05-10

Abstract excerpt

<h4>ABSTRACT</h4> It is currently understood that the characteristic loss of the repressive histone mark H3K27me3 in PFA ependymoma and diffuse midline glioma (DMG) are caused by complementary mechanisms mediated by EZHIP and the oncohistone H3K27M, respectively. To support the complementarity of these mechanisms, rare H3K27M-negative DMGs express EZHIP. Interestingly, EZHIP is one of the few genes recurrently mu...

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Literature Corpus work: 49847d75-3010-58af-8960-59b8bb02e2a4
DOI: 10.1101/2025.05.08.652913

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