Article
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.
Cell - 11 Jun 2020
Michealraj Kulandaimanuvel Antony, Kumar Sachin A, Kim Leo J Y, Cavalli Florence M G, Przelicki David, Wojcik John B, Delaidelli Alberto, Bajic Andrea, Saulnier Olivier, MacLeod Graham, Vellanki Ravi N, Vladoiu Maria C, Guilhamon Paul, Ong Winnie, Lee John J Y, Jiang Yanqing, Holgado Borja L, Rasnitsyn Alex, Malik Ahmad A, Tsai Ricky, Richman Cory M, Juraschka Kyle, Haapasalo Joonas, Wang Evan Y, De Antonellis Pasqualino, Suzuki Hiromichi, Farooq Hamza, Balin Polina, Kharas Kaitlin, Van Ommeren Randy, Sirbu Olga, Rastan Avesta, Krumholtz Stacey L, Ly Michelle, Ahmadi Moloud, Deblois Geneviève, Srikanthan Dilakshan, Luu Betty, Loukides James, Wu Xiaochong, Garzia Livia, Ramaswamy Vijay, Kanshin Evgeny, Sánchez-Osuna María, El-Hamamy Ibrahim, Coutinho Fiona J, Prinos Panagiotis, Singh Sheila, Donovan Laura K, Daniels Craig, Schramek Daniel, Tyers Mike, Weiss Samuel, Stein Lincoln D, Lupien Mathieu, Wouters Bradly G, Garcia Benjamin A, Arrowsmith Cheryl H, Sorensen Poul H, Angers Stephane, Jabado Nada, Dirks Peter B, Mack Stephen C, Agnihotri Sameer, Rich Jeremy N, Taylor Michael D
Abstract excerpt
Posterior fossa A (PFA) ependymomas are lethal malignancies of the hindbrain in infants and toddlers. Lacking highly recurrent somatic mutations, PFA ependymomas are proposed to be epigenetically driven tumors for which model systems are lacking. Here we demonstrate that PFA ependymomas are maintained under hypoxia, associated with restricted availability of specific metabolites to diminish histone methylation,...
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