Article
EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism.
Acta neuropathologica communications - 7 Nov 2025
Hasheminasabgorji Elham, Chen Huey-Miin, Gatesman Taylor A, Younes Subhi Talal, Nobles Gabrielle A, Jaryani Farhang, Mao Heather, Yu Kwanha, Deneen Benjamin, Yong Wee, Taylor Michael D, Agnihotri Sameer, Gallo Marco
Abstract excerpt
It is currently understood that the characteristic loss of the repressive histone mark H3K27me3 in PFA ependymoma and diffuse midline glioma (DMG) are caused by complementary mechanisms mediated by EZHIP and the oncohistone H3K27M, respectively. To support the complementarity of these mechanisms, rare H3K27M-negative DMGs express EZHIP. Interestingly, EZHIP is one of the few genes recurrently mutated in PFA. The...
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