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Whole-genome risk prediction of common diseases in human preimplantation embryos

1 Mar 2022

Abstract excerpt

Preimplantation genetic testing (PGT) of in-vitro-fertilized embryos has been proposed as a method to reduce transmission of common disease; however, more comprehensive embryo genetic assessment, combining the effects of common variants and rare variants, remains unavailable. Here, we used a combination of molecular and statistical techniques to reliably infer inherited genome sequence in 110 embryos and model...

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PMID: 35314819
DOI: 10.1038/s41591-022-01735-0

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