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Article

PEStimate: predicting offspring disease risk after polygenic embryo screening.

Bioinformatics (Oxford, England) - 1 Jun 2026

Klausner Liraz, Revital Ateret, Lencz Todd, Carmi Shai

Abstract excerpt

MOTIVATION: Polygenic embryo screening (PES) is a new, controversial technology, whereby human in vitro fertilization embryos are screened for their genetic risk of complex, polygenic diseases. PES aims to reduce the disease burden in offspring by prioritizing the selection of low-risk embryos. However, given that polygenic diseases are usually late-onset, PES outcomes must be estimated by epidemiological...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42135951
DOI: 10.1093/bioinformatics/btag308
PMCID: PMC13255997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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