Article

<i>PEStimate</i> : Predicting offspring disease risk after Polygenic Embryo Screening

2025-09-09

Abstract excerpt

<h4>Motivation</h4> Polygenic embryo screening (PES) is a new technology in reproductive medicine, whereby human in-vitro fertilization (IVF) embryos are screened for their genetic risk of complex, polygenic diseases. PES aims to reduce the burden of polygenic diseases in offspring by prioritizing the selection of low-risk embryos. However, given that polygenic diseases are usually late-onset, PES outcomes cannot...

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Literature Corpus work: d1cb39b9-51cb-5a4e-9d65-1216beb9fd90
DOI: 10.1101/2025.09.05.25335168

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