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Utility and First Clinical Application of Screening Embryos for Polygenic Disease Risk Reduction

3 Dec 2019

Abstract excerpt

For over 2 decades preimplantation genetic testing (PGT) has been in clinical use to reduce the risk of miscarriage and genetic disease in patients with advanced maternal age and risk of transmitting disease. Recently developed methods of genome-wide genotyping and machine learning algorithms now offer the ability to genotype embryos for polygenic disease risk with accuracy equivalent to adults. In addition,...

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PMID: 31920964
DOI: 10.3389/fendo.2019.00845

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