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Article

Utility of polygenic embryo screening for disease depends on the selection strategy.

eLife - 12 Oct 2021

Lencz Todd, Backenroth Daniel, Granot-Hershkovitz Einat, Green Adam, Gettler Kyle, Cho Judy H, Weissbrod Omer, Zuk Or, Carmi Shai

Abstract excerpt

Polygenic risk scores (PRSs) have been offered since 2019 to screen in vitro fertilization embryos for genetic liability to adult diseases, despite a lack of comprehensive modeling of expected outcomes. Here we predict, based on the liability threshold model, the expected reduction in complex disease risk following polygenic embryo screening for a single disease. A strong determinant of the potential utility of...

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Identifiers

PMID: 34635206
DOI: 10.7554/eLife.64716
PMCID: PMC8510582

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