Article

Quantitative fragmentomics allow affinity mapping of interactomes

2021-10-24

Abstract excerpt

Human protein networks have been widely explored but most binding affinities remain unknown, hindering quantitative interactome-function studies. Yet interactomes rely on minimal interacting fragments displaying quantifiable affinities. Here we measured the affinities of 65,000 interactions involving PDZ domains and their target PDZ-binding motifs (PBM) within a human interactome region particularly relevant for v...

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Identifiers and source

Literature Corpus work: 48dc2249-a724-5de5-aa0c-3e0cd159cce6
DOI: 10.1101/2021.10.22.465449

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