Article

High-Resolution Mapping of the Human E3-Substrate Interactome using Ubicon Uncovers Network Architecture and Cancer Vulnerabilities

2025-04-15

Abstract excerpt

Mapping the intricate network of E3 ubiquitin ligase-substrate interactions (ESIs), essential for cellular regulation and implicated in numerous diseases including cancer, remains a central challenge limiting mechanistic understanding. Existing experimental and computational methods suffer from limitations in throughput, accuracy, and contextual relevance. Here, we introduce Ubicon, a deep learning framework desig...

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Literature Corpus work: e9ab063b-e8e9-5b48-b445-987e60d28a3e
DOI: 10.1101/2025.04.09.647947

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