Article

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

2020-01-19

Abstract excerpt

<h4>SUMMARY</h4> Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins – half the proteome – in 293T cells and includes 118,162 i...

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Literature Corpus work: efb7800b-0f67-5953-ab76-44c60f401198
DOI: 10.1101/2020.01.19.905109

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