A single-cell survey of cellular hierarchy in acute myeloid leukemia.

doi:10.1186/s13045-020-00941-y

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Article

A single-cell survey of cellular hierarchy in acute myeloid leukemia.

Journal of hematology & oncology - 25 Sept 2020

Wu Junqing, Xiao Yanyu, Sun Jie, Sun Huiyu, Chen Haide, Zhu Yuanyuan, Fu Huarui, Yu Chengxuan, E Weigao, Lai Shujing, Ma Lifeng, Li Jiaqi, Fei Lijiang, Jiang Mengmeng, Wang Jingjing, Ye Fang, Wang Renying, Zhou Ziming, Zhang Guodong, Zhang Tingyue, Ding Qiong, Wang Zou, Hao Sheng, Liu Lizhen, Zheng Weiyan, He Jingsong, Huang Weijia, Wang Yungui, Xie Jin, Li Tiefeng, Cheng Tao, Han Xiaoping, Huang He, Guo Guoji

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) is a fatal hematopoietic malignancy and has a prognosis that varies with its genetic complexity. However, there has been no appropriate integrative analysis on the hierarchy of different AML subtypes. METHODS: Using Microwell-seq, a high-throughput single-cell mRNA sequencing platform, we analyzed the cellular hierarchy of bone marrow samples from 40 patients and 3 healthy...

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Identifiers

PMID: 32977829
DOI: 10.1186/s13045-020-00941-y
PMCID: PMC7517826

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