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The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution

5 Nov 2020

Abstract excerpt

The bone marrow microenvironment (BMM) plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression. Normal pro- and pre-B cells were found to be the most...

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PMID: 33154494
DOI: 10.1038/s41598-020-76157-4

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