Article

Characterisation of antagonist binding sites on chemokine receptor CCR4

2013-01-01

Abstract excerpt

CCR4 is a chemokine receptor notably expressed on T helper 2 and regulatory T cells. CCR4 binds the chemokines CCL17 and CCL22. These are involved in T cell homeostasis and inflammatory diseases including asthma and atopic dermatitis, making CCR4 a potential therapeutic target. Previous studies suggested that CCL22 is dominant over CCL17 with respect to ligand-induced internalisation and desensitisation of CCR4. T...

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Literature Corpus work: 48212c62-e27c-5a8c-98b7-4dab0a96ee76
DOI: 10.25560/11128

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