Article
Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation.
The Journal of biological chemistry - 15 Sept 2006
Vaidehi Nagarajan, Schlyer Sabine, Trabanino Rene J, Floriano Wely B, Abrol Ravinder, Sharma Shantanu, Kochanny Monica, Koovakat Sunil, Dunning Laura, Liang Meina, Fox James M, de Mendonça Filipa Lopes, Pease James E, Goddard William A, Horuk Richard
Abstract excerpt
A major challenge in the application of structure-based drug design methods to proteins belonging to the superfamily of G protein-coupled receptors (GPCRs) is the paucity of structural information (1). The 19 chemokine receptors, belonging to the Class A family of GPCRs, are important drug targets not only for autoimmune diseases like multiple sclerosis but also for the blockade of human immunodeficiency virus...
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