Article
Distinct conformations of the chemokine receptor CCR4 with implications for its targeting in allergy.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2014
Viney Jonathan M, Andrew David P, Phillips Rhian M, Meiser Andrea, Patel Pallavi, Lennartz-Walker Melissa, Cousins David J, Barton Nicholas P, Hall David A, Pease James E
Abstract excerpt
CC chemokine receptor 4 (CCR4) is expressed by Th2 and regulatory T cells and directs their migration along gradients of the chemokines CCL17 and CCL22. Both chemokines and receptor are upregulated in allergic disease, making CCR4 a therapeutic target for the treatment of allergy. We set out to assess the mechanisms underlying a previous report that CCL22 is a dominant ligand of CCR4, which may have implications...
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