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Article

Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians.

PLoS genetics - 1 Dec 2014

Pierce Brandon L, Tong Lin, Chen Lin S, Rahaman Ronald, Argos Maria, Jasmine Farzana, Roy Shantanu, Paul-Brutus Rachelle, Westra Harm-Jan, Franke Lude, Esko Tonu, Zaman Rakibuz, Islam Tariqul, Rahman Mahfuzar, Baron John A, Kibriya Muhammad G, Ahsan Habibul

Abstract excerpt

A large fraction of human genes are regulated by genetic variation near the transcribed sequence (cis-eQTL, expression quantitative trait locus), and many cis-eQTLs have implications for human disease. Less is known regarding the effects of genetic variation on expression of distant genes (trans-...

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Identifiers

PMID: 25474530
DOI: 10.1371/journal.pgen.1004818
PMCID: PMC4256471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25474530-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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