Article

Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis

2016-09-30

Abstract excerpt

<h4>ABSTRACT</h4> The impact of inherited genetic variation on gene expression in humans is well-established. The majority of known expression quantitative trait loci (eQTLs) impact expression of local genes (cis-eQTLs). More research is needed to identify effects of genetic variation on distant genes (trans-eQTLs) and understand their biological mechanisms. One common trans-eQTLs mechanism is “mediation” by a lo...

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Literature Corpus work: 16b438d5-0ff8-5d02-9747-fa51d6b236bb
DOI: 10.1101/078683

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