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Article

Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits.

American journal of human genetics - 6 Apr 2017

Yao Chen, Joehanes Roby, Johnson Andrew D, Huan Tianxiao, Liu Chunyu, Freedman Jane E, Munson Peter J, Hill David E, Vidal Marc, Levy Daniel

Abstract excerpt

Identifying causal genetic variants and understanding their mechanisms of effect on traits remains a challenge in genome-wide association studies (GWASs). In particular, how genetic variants (i.e., trans-eQTLs) affect expression of remote genes (i.e., trans-eGenes) remains unknown. We hypothesized that some trans-eQTLs regulate expression of distant genes by altering the expression of nearby genes (cis-eGenes)....

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Source

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Identifiers

PMID: 28285768
DOI: 10.1016/j.ajhg.2017.02.003
PMCID: PMC5384035

Genes

ALDH2
MCM6
TAGAP
TRIB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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