Article

Quantifying mediation between omics layers and complex traits

2021-10-01

Abstract excerpt

<h4>Background</h4> High-dimensional omics datasets provide valuable resources to determine the causal role of molecular traits in mediating the path from genotype to phenotype. Making use of quantitative trait loci (QTL) and genome-wide association studies (GWASs) summary statistics, we developed a multivariable Mendelian randomization (MVMR) framework to quantify the connectivity between three omics layers (DNA...

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Literature Corpus work: 38f422e8-abbd-528e-8bf0-539547390721
DOI: 10.1101/2021.09.29.462396

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