Article

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

2019-10-30

Abstract excerpt

<h4>SUMMARY</h4> DNA methylation is a key epigenetic modification in human development and disease, yet there is limited understanding of its highly coordinated regulation. Here, we identified 818 genes that influence DNA methylation patterns in blood using large-scale population genomics data. By employing genetic instruments as causal anchors, we identified directed associations between gene expression and dist...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d69fa47-7fca-5c38-995d-353c0cd1dcb6
DOI: 10.1101/823807

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inferenceDOI 10.1101/823807Read

Genetic impacts on DNA methylation help elucidate regulatory genomic processesSemantic proximity Read

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic dataSemantic proximity Read

Genetic impacts on DNA methylation help elucidate regulatory genomic processes.Semantic proximity Read

Leveraging DNA methylation quantitative trait loci to characterize the relationship between methylomic variation, gene expression and complex traitsSemantic proximity Read

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data.Semantic proximity Read

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.Semantic proximity Read

Genomic and phenomic insights from an atlas of genetic effects on DNA methylationSemantic proximity Read

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.Semantic proximity Read

Genetic regulation of DNA methylation across tissues reveals thousands of molecular links to complex traitsSemantic proximity Read

Exploring the Genetic Basis of Human Population Differences in DNA Methylation and their Causal Impact on Immune Gene RegulationSemantic proximity Read

Genetic impacts on DNA methylation: research findings and future perspectives.Semantic proximity Read

Efficient and accurate causal inference with hidden con-founders from genome-transcriptome variation dataSemantic proximity Read