Article

Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant

2020-05-14

Abstract excerpt

Glucose-dependent insulinotropic polypeptide ( GIP ) has a role in controlling postprandial metabolic tone. In humans, a GIP receptor ( GIPR ) variant (Q354, rs1800437) is associated with a lower body mass index ( BMI ) and increased risk for Type 2 Diabetes. To isolate the contribution of GIPR in metabolic control, we generated a mouse model of the GIPR-Q354 variant (GIPR-Q350 mice). Female GIPR-Q350 mice are...

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Literature Corpus work: 480a7e5f-f1ea-5175-95b1-5ee7b342a19a
DOI: 10.1101/2020.05.12.091025

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