Article

Ligand-independent modulation of GIPR signaling by splice variants

2022-01-24

Abstract excerpt

Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a potential drug target for metabolic disorders. It works with glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) in humans to maintain glucose homeostasis. Unlike the other two receptors, GIPR has at least 7 reported (EMBL-EBI, 2022; NCBI, 2022a, 2022b) splice variants (SVs) with previously undefined functions. To explore their ro...

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Literature Corpus work: ad815c0e-6fd1-5e36-bb2e-024e575de005
DOI: 10.1101/2022.01.24.477496

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