Article

Myeloid Gi signaling acts as a weight-independent immunometabolic switch controlling systemic insulin sensitivity

2026-03-31

Abstract excerpt

Metabolic dysfunction does not necessarily correlate with adiposity. Metabolically healthy obese individuals and insulin-resistant lean individuals represent a fundamental paradox that implicates immune cell intrinsic mechanisms in the pathogenesis of type 2 diabetes. Here, we identify myeloid Gi signaling as a previously unrecognized determinant of whole-body glucose homeostasis. Single-cell transcriptomic analys...

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Literature Corpus work: 942e22e0-dceb-5340-8761-c63d19226f1a
DOI: 10.64898/2026.03.28.713834

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