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Article

A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity.

Molecular and cellular biology - 1 Oct 2014

Mohammad Sameer, Patel Rajesh T, Bruno Joanne, Panhwar Muhammad Siyab, Wen Jennifer, McGraw Timothy E

Abstract excerpt

Glucose-dependent insulinotropic polypeptide (GIP), an incretin hormone secreted from gastrointestinal K cells in response to food intake, has an important role in the control of whole-body metabolism. GIP signals through activation of the GIP receptor (GIPR), a G-protein-coupled receptor (GPCR). Dysregulation of this pathway has been implicated in the development of metabolic disease. Here we demonstrate that...

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Source

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Identifiers

PMID: 25047836
DOI: 10.1128/MCB.00256-14
PMCID: PMC4187723

Genes

GIP
GIPR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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