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Article

Glycemic and bodyweight effects of GIPR coding variation reflect differences in surface expression and intrinsic functional impairment.

Science advances - 4 Sept 2026

Manchanda Yusman, Desoki Rofaida, Gardner Eugene J, Perry John R B, Wainscott David B, Stutsman Cynthia, Langenberg Claudia, Coghlan Matthew, Bhatnagar Pallav, Ho Joseph D, Yonkunas Michael, Sloop Kyle W, Ong Ken K, Wareham Nicholas J, Tomas Alejandra, Jones Ben

Abstract excerpt

The glucose-dependent insulinotropic polypeptide receptor (GIPR) is a major therapeutic target in type 2 diabetes and obesity. Missense variation in GIPR could confer phenotypic effects through alterations to constitutive activity or functional responses to GIP or pharmacological agonists. In this study, we aimed to provide a deep understanding of the molecular mechanisms that underpin the cellular and...

Read the complete abstract on PubMed

Topics

Humans
Receptors, Gastrointestinal Hormone
Molecular Dynamics Simulation
Animals
Blood Glucose

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Islets of Langerhans

Genetic Variation

Cyclic AMP

Source

Open in PubMed Open full text

Identifiers

PMID: 42696562
DOI: 10.1126/sciadv.aec3372
PMCID: PMC13544220

Genes

GIPR
GIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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