Article

Altered desensitization and internalization patterns of rodent versus human GIP receptors -- a major drug discovery challenge

2023-07-03

Abstract excerpt

Background and Purpose The gut hormone glucose-dependent insulinotropic polypeptide (GIP) signals via the GIP receptor (GIPR) resulting in postprandial processes such as potentiation of glucose-stimulated insulin secretion. Translation of results from rodent to human studies has, however, been challenged by contradictive therapeutic effects of GIPR-targeting compounds. We, therefore, investigated the variation bet...

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Literature Corpus work: de6533da-8c23-5a87-a8d3-01a2abf8373a
DOI: 10.22541/au.168837507.72959473/v1

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