Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes.

doi:10.1038/s42255-024-01061-4

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Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes.

Nature metabolism - 1 Jul 2024

Kizilkaya Hüsün S, Sørensen Kimmie V, Madsen Jakob S, Lindquist Peter, Douros Jonathan D, Bork-Jensen Jette, Berghella Alessandro, Gerlach Peter A, Gasbjerg Lærke S, Mokrosiński Jacek, Mowery Stephanie A, Knerr Patrick J, Finan Brian, Campbell Jonathan E, D'Alessio David A, Perez-Tilve Diego, Faas Felix, Mathiasen Signe, Rungby Jørgen, Sørensen Henrik T, Vaag Allan, Nielsen Jens S, Holm Jens-Christian, Lauenborg Jeannet, Damm Peter, Pedersen Oluf, Linneberg Allan, Hartmann Bolette, Holst Jens J, Hansen Torben, Wright Shane C, Lauschke Volker M, Grarup Niels, Hauser Alexander S, Rosenkilde Mette M

Abstract excerpt

Incretin-based therapies are highly successful in combatting obesity and type 2 diabetes1. Yet both activation and inhibition of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in combination with glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) activation have resulted in similar clinical outcomes, as demonstrated by the GIPR-GLP-1R co-agonist tirzepatide2 and AMG-133 (ref. 3) combining...

Topics

Receptors, Gastrointestinal Hormone
Animals
Mice
Humans
Phenotype
beta-Arrestins
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

beta-Arrestin 2

Signal Transduction

Gastric Inhibitory Polypeptide

Diabetes Mellitus, Type 2

Obesity

Male

Glucagon-Like Peptide-1 Receptor

Source

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Identifiers

PMID: 38871982
DOI: 10.1038/s42255-024-01061-4
PMCID: PMC11272584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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