Article
Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region.
Diabetes - 1 Nov 2021
Bowker Nicholas, Hansford Robert, Burgess Stephen, Foley Christopher N, Auyeung Victoria P W, Erzurumluoglu A Mesut, Stewart Isobel D, Wheeler Eleanor, Pietzner Maik, Gribble Fiona, Reimann Frank, Bhatnagar Pallav, Coghlan Matthew P, Wareham Nicholas J, Langenberg Claudia
Abstract excerpt
There is considerable interest in GIPR agonism to enhance the insulinotropic and extrapancreatic effects of GIP, thereby improving glycemic and weight control in type 2 diabetes (T2D) and obesity. Recent genetic epidemiological evidence has implicated higher GIPR-mediated GIP levels in raising coronary artery disease (CAD) risk, a potential safety concern for GIPR agonism. We therefore aimed to quantitatively...
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