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Glycaemic and bodyweight effects of <i>GIPR</i> coding variation reflect differences in both surface expression and intrinsic functional impairment

2025-08-19

Abstract excerpt

The glucose-dependent insulinotropic polypeptide receptor (GIPR) is the target of several approved and investigational drugs for type 2 diabetes and obesity. Missense coding variation in GIPR could confer phenotypic effects through altered constitutive or functional responses to GIP or alter the efficacy of pharmacological agents targeting this receptor. We aimed to provide a deep understanding of the cellular and...

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Literature Corpus work
e5120832-2603-536c-8994-b59aa1788585
DOI
10.1101/2025.08.15.25333807
Open publication

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Glycaemic and bodyweight effects of <i>GIPR</i> coding variation reflect differences in both surface expression and intrinsic functional impairmentDOI 10.1101/2025.08.15.25333807
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