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Genetically proxied impaired GIPR signaling and risk of 6 cancers

9 May 2023

Abstract excerpt

Preclinical and genetic studies suggest that impaired glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling worsens glycemic control. The relationship between GIPR signaling and the risk of cancers influenced by impaired glucose homeostasis is unclear. We examined the association of a variant in GIPR , rs1800437 (E354Q), shown to impair long-term GIPR signaling and lower circulating...

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PMID: 37250804
DOI: 10.1016/j.isci.2023.106848

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