Article

The mechanism of HIV-1 Nef-mediated downregulation of CD4

2010-01-01

Abstract excerpt

Nef, an accessory protein of HIV-1, is a critical determinant of viral pathogenicity. The pathogenic effects of Nef are in large part dependent on its ability to decrease the amount of CD4 on the surface of infected cells. Early studies suggested that Nef induces downregulation by linking the cytosolic tail of CD4 to components of the host-cell protein-trafficking machinery. However, the specific sorting pathway t...

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Literature Corpus work: 47e43300-9904-5430-b854-3b083e6dd102
DOI: 10.17863/cam.15875

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